Paleo-environmental information present that the distribution of African rain forests was affected by Quaternary local weather modifications. In specific, the Dahomey Gap (DG) – a 200 km large savanna hall presently separating the West African and Central African rain forest blocks and containing relict rain forest fragments – was forested throughout the mid-Holocene and presumably throughout earlier interglacial durations, whereas it was dominated by open vegetation (savanna) throughout glacial durations. Genetic signatures of previous inhabitants fragmentation and demographic modifications have been discovered in some African forest plant species utilizing nuclear markers, however such occasions seem to not have been synchronous or shared throughout species.
To higher perceive the colonization historical past of the DG by rain forest trees by means of seed dispersal, the plastid genomes of two widespread African forest legume trees, Anthonotha macrophylla and Distemonanthus benthamianus, had been sequenced in 47 people for every species, offering unprecedented phylogenetic decision of their maternal lineages (857 and 115 SNPs, respectively). Both species exhibit distinct lineages separating three areas: 1. Upper Guinea (UG, i.e. the West African forest block), 2. the space ranging from the DG to the Cameroon volcanic line (CVL), and three. Lower Guinea (LG, the western a part of the Central African forest block) the place three lineages co-occur.
In each species, the DG populations (together with southern Nigeria west of Cross River) exhibit a lot decrease genetic range than UG and LG populations, and their plastid lineages originate from the CVL, confirming the position of the CVL as an historical forest refuge. Despite the related phylogeographic constructions displayed by A. macrophylla and D. benthamianus, molecular courting signifies very contrasting ages of lineage divergence (UG diverged from LG since c. 7 Ma and 0.7 Ma, respectively) and DG colonization (most likely following the Mid Pleistocene Transition and the Last Glacial Maximum, respectively). The stability of forest refuge areas and repeated related forest shrinking/increasing occasions throughout successive glacial durations may clarify why related phylogeographic patterns could be generated over contrasting timescales.
Genetic range and inferred dispersal historical past of the Schlegel’s Japanese Gecko (Gekko japonicus) in Northeast Asia primarily based on inhabitants genetic analyses and paleo-species distribution modelling.
To perceive the genetic range and dispersal historical past of Schlegel’s Japanese gecko (Gekko japonicus), we carried out genetic analyses and paleo-species distributional modelling. For the genetic evaluation, we analyzed mitochondrial DNA (mtDNA) (cytochrome b [Cytb] and NADH dehydrogenase 2 [ND2]) and 7 microsatellite loci of 353 people from 11 populations (2 east coast China, four west and central coast Japan and 5 Korea). For the paleo-species distribution modelling, we used 432 incidence information factors (125 China, 291 Japan and 16 Korea) over the Pleistocene and Holocene.
China is inferred to be the supply inhabitants, which had increased genetic range (mtDNA) and extra personal alleles (mtDNA) in comparison with Japanese and Korean populations. Differences between the three counties had been very small in the mtDNA haplotype community regardless of some genetic construction amongst the three nations. Microsatellite evaluation inferred that genetic alternate has actively occurred amongst the Chinese, Japanese and Korean populations. Suitable habitats in Japan ought to have been plentiful by the mid-Holocene, however have solely lately develop into accessible in Korea. These outcomes counsel that dispersal of G. japonicus occurred after the Holocene warming from the east coast of China to the west and central coasts of Japan and Korea, and gene circulate is actively occurring amongst the three nations.
Geological and Climatic Factors Affect the Population Genetic Connectivity in Mirabilis himalaica (Nyctaginaceae): Insight From Phylogeography and Dispersal Corridors in the Himalaya-Hengduan Biodiversity Hotspot.
The genetic structure inside a species in the Himalaya-Hengduan Mountains (HHM) area was thought of as the consolidated consequence of historic orogenesis and climatic oscillations. The visualization of dispersal corridors as the operate of inhabitants genetic connectivity grew to become essential to elucidate the spatiotemporal dynamics of organisms. However, geodiversity and bodily boundaries created by paleo geo-climatic occasions acted vigorously to influence notable alterations in the phylogeographic sample and dispersal corridors. Therefore, to realize detailed phylogeography, find dispersal corridors and estimate genetic connectivity
we built-in phylogeography with species distribution modelling and least value path of Mirabilis himalaica (Edgew.) Heimerl in the HHM. We amplified 4 cpDNA areas (petL-psbE, rpstrnK, rpstrnS-trnG), and a low copy nuclear gene (G3pdh) from 241 people of 29 populations. SAMOVA, genealogical relationships, and phylogenetic evaluation revealed 4 spatially structured phylogroups for M. himalaica with the onset of diversification in late Pliocene (c. 3.64 Ma). No current demographic progress was supported by outcomes of neutrality assessments, mismatch distribution evaluation and Bayesian skyline plot.
Luciferase Reporter Assay Kit |
K2181-200 |
ApexBio |
200 assays |
EUR 130 |
Luciferase Reporter Assay Kit |
K801-200 |
Biovision |
each |
EUR 235.2 |
Dual Luciferase Reporter Assay Kit |
DL101-01 |
Vazyme |
100 rxn |
EUR 90.5 |
Single-Luciferase Reporter Assay Kit |
20-abx098133 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
Double-Luciferase Reporter Assay Kit |
20-abx098134 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
Single-Luciferase Reporter Assay Kit |
abx098133-100l |
Abbexa |
100 µl |
EUR 650 |
Single-Luciferase Reporter Assay Kit |
abx098133-1ml |
Abbexa |
1 ml |
Ask for price |
Single-Luciferase Reporter Assay Kit |
abx098133-200l |
Abbexa |
200 µl |
EUR 762.5 |
Double-Luciferase Reporter Assay Kit |
abx098134-100l |
Abbexa |
100 µl |
EUR 687.5 |
Double-Luciferase Reporter Assay Kit |
abx098134-1ml |
Abbexa |
1 ml |
Ask for price |
Double-Luciferase Reporter Assay Kit |
abx098134-200l |
Abbexa |
200 µl |
EUR 900 |
PDE1B Cell-Based Reporter Assay Kit |
GWB-PS8329 |
GenWay Biotech |
500reactions |
Ask for price |
Luciferase Reporter Gene Assay Kit |
Z5030001 |
Biochain |
200 assays |
EUR 329 |
Luciferase Reporter Gene Assay Kit |
Z5030002 |
Biochain |
500 assays |
EUR 636 |
Luciferase Reporter Gene Assay Kit |
Z5030003 |
Biochain |
1,000 assays |
EUR 1118 |
Single-Luciferase (Renilla) Reporter Assay Kit |
20-abx298011 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
Single-Luciferase (Renilla) Reporter Assay Kit |
abx298011-100g |
Abbexa |
100 µg |
Ask for price |
Single-Luciferase (Renilla) Reporter Assay Kit |
abx298011-20g |
Abbexa |
20 µg |
EUR 675 |
Single-Luciferase (Renilla) Reporter Assay Kit |
abx298011-50g |
Abbexa |
50 µg |
EUR 850 |
Notch Signaling Pathway Notch1/CSL Reporter - HEK293 Cell Line |
60652 |
BPS Bioscience |
2 vials |
EUR 2175 |
Description: The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by γ-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway. |
Dual Luciferase Reporter Gene Assay Kit |
KTA8010-1000T |
Abbkine |
1000 T |
EUR 819 |
Dual Luciferase Reporter Gene Assay Kit |
KTA8010-100T |
Abbkine |
100 T |
EUR 149 |
Dual Luciferase Reporter Gene Assay Kit |
KTA8010-each |
Abbkine |
each |
Ask for price |
Notch1 Pathway Reporter Kit (Human) |
79503 |
BPS Bioscience |
500 rxns. |
EUR 650 |
Description: Notch Pathway Reporter kit is designed for monitoring the activity of the Notch signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for Human NOTCH1 that has a deletion of the entire extracellular domain, leaving the transmembrane and intracellular domains intact (Notch1DE). Inside the cells, the NOTCH1 DE is cleaved by γ-secretase and active NOTCH1 NICD is released into the nucleus. The kit also contains CSL (CBF1/RBP-Jk) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized CSL responsive elements upstream of a minimal promoter. The CSL (CBF1/RBP-Jk) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity._x000D_This kit contains the expression vector for Human Notch1DE. We also offer the Mouse Notch1DE expression vector (BPS Bioscience #60509), as well as a Mouse Notch1 NICD expression vector, which is constitutively active without processing by γ-secretase (BPS Bioscience #79504)._x000D_ |
Human Notch Signaling Pathway Notch1/CSL Reporter Cell Line-HEK293 |
ABC-RC0116 |
AcceGen |
1 vial |
Ask for price |
Description: Human Notch Signaling Pathway Notch1/CSL Reporter Cell Line is derived from HEK293. Application: • Monitor Notch signaling pathway activity.• Screen for activators or inhibitors of the Notch signaling pathway. |
RARα Reporter Cellular Assay Pack |
79322 |
BPS Bioscience |
2 vials |
EUR 2390 |
Description: The RARα Reporter Cellular Assay Pack provides all the key reagents required to monitor the activity of retinoic acid receptor alpha (RARα). The pack contains the RARα Reporter (Luc)-HEK293 Cell Line, a luciferase reporter cell line that contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARα (GenBank Accession No. NM_000964). This cell line is functionally validated for the response to the stimulation of all-trans retinoic acid, and the expression of RARα is confirmed by Western blotting._x000D_Additionally, the pack includes cell culture medium (Thaw Medium 6) that has been optimized for use with HEK293 cells. Thaw Medium 6 includes 10% fetal bovine serum and 1% Pen/Strep. Finally, the pack provides the ONE-Step™ Luciferase Detection System. This reagent provides highly sensitive, stable detection of firefly (Photinus pyralis) luciferase activity. The ONE-Step luciferase reagent can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required. |
RARβ Reporter Cellular Assay Pack |
79323 |
BPS Bioscience |
2 vials |
EUR 2050 |
Description: The RARβ Reporter Cellular Assay Pack provides all the key reagents required to monitor the activity of retinoic acid receptor beta (RARβ). The pack contains the RARβ Reporter (Luc)-HEK293 Cell Line, a luciferase reporter cell line that contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARα (GenBank Accession No. P10826-2). This cell line is functionally validated for the response to the stimulation of all-trans retinoic acid, and the expression of RARβ is confirmed by Western blotting._x000D_Additionally, the pack includes cell culture medium (Thaw Medium 6) that has been optimized for use with HEK293 cells. Thaw Medium 6 includes 10% fetal bovine serum and 1% Pen/Strep. Finally, the pack provides the ONE-Step™ Luciferase Detection System. This reagent provides highly sensitive, stable detection of firefly (Photinus pyralis) luciferase activity. The ONE-Step luciferase reagent can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required. |
RARγ Reporter Cellular Assay Pack |
79324 |
BPS Bioscience |
2 vials |
EUR 2050 |
Description: The RARγ Reporter Cellular Assay Pack provides all the key reagents required to monitor the activity of retinoic acid receptor gamma (RARγ). The pack contains the RARγ Reporter (Luc)-HEK293 Cell Line, a luciferase reporter cell line that contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARα (GenBank Accession No. P13631-1). This cell line is functionally validated for the response to the stimulation of all-trans retinoic acid, and the expression of RARγ is confirmed by Western blotting._x000D_Additionally, the pack includes cell culture medium (Thaw Medium 6) that has been optimized for use with HEK293 cells. Thaw Medium 6 includes 10% fetal bovine serum and 1% Pen/Strep. Finally, the pack provides the ONE-Step™ Luciferase Detection System. This reagent provides highly sensitive, stable detection of firefly (Photinus pyralis) luciferase activity. The ONE-Step luciferase reagent can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required. |
Notch1 NICD Pathway Reporter Kit (Mouse) |
79504 |
BPS Bioscience |
500 rxns. |
EUR 590 |
Description: Notch Pathway Reporter kit is designed for monitoring the activity of the Notch signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for Mouse NOTCH1 that has a deletion of the entire extracellular domain and transmembrane region (NOTCH1 NICD). Inside the cells, the NOTCH1 NICD is constitutively localized into the nucleus without needing to be cleaved by γ-secretase. The kit also contains CSL (CBF1/RBP-Jκ) luciferase reporter vector, which is a Notch pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized CSL responsive elements upstream of a minimal promoter. The CSL (CBF1/RBP-Jκ) reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway specific effects and background luciferase activity._x000D_This kit contains the expression vector for Mouse Notch1 NICD, which does not require γ-secretase processing to become active. We also offer the Mouse Notch1DE expression vector (BPS Bioscience #60509), as well as a Human Notch1DE expression vector (BPS Bioscience #79503), which are dependent on γ-secretase activity to become active. |
Amplite® Luciferase Reporter Gene Assay Kit *Bright Glow* |
12518-1plate |
AAT Bioquest |
1 plate |
EUR 166 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Luciferase Reporter Gene Assay Kit *Bright Glow* |
12519-10plates |
AAT Bioquest |
10 plates |
EUR 446 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Luciferase Reporter Gene Assay Kit *Bright Glow* |
12520-100plates |
AAT Bioquest |
100 plates |
EUR 3321 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
NF-κB Reporter Cellular Assay Pack (CHOK1) |
79325 |
BPS Bioscience |
2 vials |
EUR 1245 |
Description: The NF-κB Reporter Cellular Assay Pack provides all the key reagents required to monitor the activity of the nuclear factor Kappa B (NF-κB) signal transduction pathways. The pack contains the NF-κB Reporter (Luc)- CHO-K1 Recombinant Cell Line, a luciferase reporter cell line that contains a firefly luciferase gene under the control of four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or stimulants of lymphokine receptors, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene. This cell line is validated for the response to TNFalpha and to treatment with NF-κB inhibitor, evodiamine. _x000D_Additionally, the pack includes cell culture medium (Thaw Medium 3) that has been optimized for use with CHO-K1 cells. Thaw Medium 3 includes 10% fetal bovine serum and 1% Pen/Strep. Finally, the pack provides the ONE-Step™ Luciferase Detection System. This reagent provides highly sensitive, stable detection of firefly (Photinus pyralis) luciferase activity. The ONE-Step luciferase reagent can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required. |
NF-κB Reporter Cellular Assay Pack (HCT116) |
79326 |
BPS Bioscience |
2 vials |
EUR 1245 |
Description: The NF-κB Reporter Cellular Assay Pack provides all the key reagents required to monitor the activity of the nuclear factor Kappa B (NF-κB) signal transduction pathways. The pack contains the NF-κB Reporter (Luc)- HCT-116 Recombinant Cell Line, a luciferase reporter cell line that contains a firefly luciferase gene under the control of four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or stimulants of lymphokine receptors, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene. This cell line is validated for the response to TNFalpha and to treatment with NF-κB inhibitor, evodiamine._x000D_Additionally, the pack includes cell culture medium (Thaw Medium 7) that has been optimized for use with HCT-116 cells. Thaw Medium 7 includes 10% fetal bovine serum and 1% Pen/Strep. Finally, the pack provides the ONE-Step™ Luciferase Detection System. This reagent provides highly sensitive, stable detection of firefly (Photinus pyralis) luciferase activity. The ONE-Step luciferase reagent can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required._x000D__x000D_ |
NF-κB Reporter Cellular Assay Pack (HEK293) |
79327 |
BPS Bioscience |
2 vials |
EUR 1515 |
Description: The NF-κB Reporter Cellular Assay Pack provides all the key reagents required to monitor the activity of the nuclear factor Kappa B (NF-κB) signal transduction pathways. The pack contains the NF-κB Reporter (Luc)-HEK293 Recombinant Cell Line, a luciferase reporter cell line that contains a firefly luciferase gene under the control of four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or stimulants of lymphokine receptors, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene. This cell line is validated for the response to TNFalpha and to treatment with NF-κB inhibitor, evodiamine._x000D_Additionally, the pack includes cell culture medium (Thaw Medium 1) that has been optimized for use with HEK293 cells. Thaw Medium 1 includes 10% fetal bovine serum, non-essential amino acids, sodium pyruvate, and 1% Pen/Strep. Finally, the pack provides the ONE-Step™ Luciferase Detection System. This reagent provides highly sensitive, stable detection of firefly (Photinus pyralis) luciferase activity. The ONE-Step luciferase reagent can be used directly in cells in growth medium, and can be detected with any luminometer; automated injectors are not required._x000D_ |
Amplite® Luciferase Reporter Gene Assay Kit *Maximized Luminescence* |
12519 |
AAT Bioquest |
10 plates |
EUR 455 |
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
12530-1plate |
AAT Bioquest |
1 plate |
EUR 222 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
12531-10Plates |
AAT Bioquest |
10 Plates |
EUR 846 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
12532-100plates |
AAT Bioquest |
100 plates |
EUR 4447 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
12535-1plate |
AAT Bioquest |
1 plate |
EUR 222 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
12536-10plates |
AAT Bioquest |
10 plates |
EUR 1070 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
12537-100plates |
AAT Bioquest |
100 plates |
EUR 4447 |
|
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Amplite® Renilla Luciferase Reporter Gene Assay Kit *Maximized Luminescence* |
12536 |
AAT Bioquest |
10 plates |
EUR 1092 |
Description: Common reporter genes include beta-galactosidase, beta-glucuronidase and luciferase. |
Dual Notch1-YFP and Inducible Delta-mCherry Reporter CHO-K1 (hN1) Cell Line |
T3032 |
ABM |
1x10^6 cells / 1.0 ml |
EUR 3950 |
CRE/CRE Reporter Kit |
GWB-PS935F |
GenWay Biotech |
500reactions |
Ask for price |
WNT TCF/LEF reporter kit |
GWB-PS656B |
GenWay Biotech |
500rxns. |
Ask for price |
AP1 Reporter Kit (JNK Pathway) |
60612 |
BPS Bioscience |
500 rxns. |
EUR 565 |
Description: The AP1 Reporter Kit is designed for monitoring the activity of the JNK signaling pathway and the transcriptional activity of AP1 in cultured cells. The kit contains a transfection-ready AP1 luciferase reporter vector. This reporter contains the firefly luciferase gene under the control of multimerized AP1 responsive elements located upstream of a minimal promoter. The AP1 reporter is premixed with a constitutively-expressing Renilla (sea pansy) luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical for determining pathway-specific effects and the background luciferase activity. |
AP1 Reporter Kit (JNK Pathway) |
GWB-PSB7DB |
GenWay Biotech |
500reactions |
Ask for price |
Dual Notch1(Variant)-YFP and Inducible Delta-mCherry Reporter CHO-K1 (hN1G4<sup>esn</sup>) Cell Line |
T3033 |
ABM |
1x10^6 cells / 1.0 ml |
EUR 3950 |
pLuc Reporter Vector |
110000 |
CH3 BioSystems |
each |
EUR 135 |
Description: A lucife |
FOXO Reporter Kit (PI3K/AKT Pathway) |
60643 |
BPS Bioscience |
500 rxns. |
EUR 565 |
Description: The FOXO Reporter kit is designed to monitor activity of the PI3K/AKT signaling pathway and the transcriptional activity of FOXO proteins in cultured cells. The kit contains the transfection-ready FOXO3 expression vector and the FOXO luciferase reporter vector, which is a PI3K/Akt pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimers of the FOXO responsive element located upstream of a minimal promoter. The FOXO reporter is premixed with a constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal control for the transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as negative control. The non-inducible luciferase vector also contains the firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity. |
Myc Reporter Kit (Myc Signaling Pathway) |
60519 |
BPS Bioscience |
500 rxns. |
EUR 625 |
Description: The Myc Pathway Reporter kit is designed for monitoring the activity of the Myc signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for c- Myc and Myc luciferase reporter vector. Inside the cells, c-Myc will bind to Max, translocate to the nucleus, and induce expression of the Myc luciferase reporter vector. This reporter contains the firefly luciferase gene under the control of multimerized Myc responsive elements located upstream of a minimal promoter. The Myc reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway-specific effects and background luciferase activity. |
ARE Reporter Kit (Nrf2 Antioxidant Pathway ) |
60514 |
BPS Bioscience |
500 rxns. |
EUR 650 |
Description: The ARE Reporter kit is designed for monitoring the activity of the Nrf2 antioxidant pathway in cultured cells. The kit contains a transfection-ready ARE luciferase reporter vector, which is an Nrf2 pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized ARE responsive elements located upstream of a minimal promoter. The ARE reporter is premixed with a constitutively expressing Renilla (sea pansy) luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively expressing Renilla luciferase vector as negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. This negative control is critical to determining pathway-specific effects and background luciferase activity. |
STAT3 Reporter Kit (STAT3 Signaling Pathway) |
79730 |
BPS Bioscience |
500 rxns. |
EUR 640 |
Description: The STAT3 Reporter kit is designed for monitoring the activity of the STAT3 signaling pathway in cultured cells. The kit contains transfection-ready STAT3 luciferase reporter vector. This reporter contains a firefly luciferase gene under the control of STAT3-responsive element located upstream of a minimal promoter. The STAT3 reporter is premixed with constitutively expressing Renilla luciferase vector, which serves as an internal control for transfection efficiency._x000D_ The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity. |
RARbeta Reporter Cell Line |
GWB-PS5D33 |
GenWay Biotech |
~2x10(6)cells |
Ask for price |
RARalpha Reporter Cell Line |
GWB-PSA34A |
GenWay Biotech |
~2x10(6)cells |
Ask for price |
RARgamma Reporter Cell Line |
GWB-PSB42E |
GenWay Biotech |
~2x10(6)cells |
Ask for price |
TCF/LEF Reporter Kit (Wnt Signaling Pathway) |
60500 |
BPS Bioscience |
500 rxns. |
EUR 655 |
Description: The TCF/LEF Reporter kit is designed for monitoring the activity of Wnt / β-catenin signaling pathway in the cultured cells. The kit contains transfection-ready TCF/LEF luciferase reporter vector, which is a Wnt pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized TCF/LEF responsive element located upstream of a minimal promoter. The TCF/LEF reporter is premixed with constitutively-expressing Renilla luciferase vector that serves as internal control for transfection efficiency. _x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway specific effects and background luciferase activity. _x000D_ |
SRE Reporter Kit (MAPK/ERK Signaling Pathway ) |
60511 |
BPS Bioscience |
500 rxns. |
EUR 595 |
Description: The SRE Reporter Kit is designed for monitoring the activity of the ERK signaling pathway and the transcriptional activity of SRF in cultured cells. The kit contains a transfection-ready SRE luciferase reporter vector, which is an ERK pathway-responsive reporter. This reporter contains the firefly luciferase gene under the control of multimerized SRE responsive elements located upstream of a minimal promoter. The SRE reporter is premixed with a constitutively-expressing Renilla (sea pansy) luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical for determining pathway-specific effects and the background luciferase activity. |
SRE Reporter Kit (MAPK/ERK Signaling Pathway ) |
GWB-PS60EE |
GenWay Biotech |
500reactions |
Ask for price |
NFAT eGFP Reporter Lentivirus |
79922 |
BPS Bioscience |
500 µl x 2 |
EUR 875 |
Description: The NFAT eGFP Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an enhanced GFP gene driven by the NFAT response element located upstream of the minimal TATA promoter. After transduction, activation of the NFAT signaling pathway in the target cells can be monitored by examining eGFP expression._x000D_ |
Reporter cell line generation |
S302 |
101Bio |
- |
EUR 15000 |
ISRE Reporter Kit (JAK/STAT Signaling Pathway) |
60613 |
BPS Bioscience |
500 rxns. |
EUR 565 |
Description: The ISRE Reporter kit is designed for monitoring the activity of Type I interferon-induced JAK/STAT signaling pathway in the cultured cells. The kit contains transfection-ready ISRE luciferase reporter vector, which is a JAK/STAT pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized ISRE responsive element located upstream of a minimal promoter. The ISRE reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The noninducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway specific effects and background luciferase activity. |
SBE Reporter Kit (TGFβ/SMAD signaling pathway) |
60654 |
BPS Bioscience |
500 rxns. |
EUR 595 |
Description: The SBE Reporter kit is designed for monitoring the activity of TGFβ/SMAD signaling pathway in the cultured cells. The kit contains transfection-ready SBE luciferase reporter vector, which is a TGFβ pathway-responsive reporter. This reporter contains a firefly luciferase gene under the control of multimerized SBE responsive element located upstream of a minimal promoter. The SBE reporter is premixed with constitutively-expressing Renilla luciferase vector that serves as internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as negative control. The noninducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity. |
FOXO Reporter Kit (PI3K/AKT Signaling Pathway) |
GWB-PS252F |
GenWay Biotech |
500reactions |
Ask for price |
STAT3 eGFP Reporter Lentivirus |
78197 |
BPS Bioscience |
500 µl x 2 |
EUR 795 |
Description: The STAT3 eGFP Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an eGFP gene under the control of a STAT3-responsive element located upstream of the minimal TATA promoter . After transduction, activation of the STAT3 signaling pathway in the target cells can be monitored by examining eGFP expression. |
Human ARE Reporter Cell Line |
ABC-RC0079 |
AcceGen |
1 vial |
Ask for price |
Description: Human ARE Reporter Cell Line are suitable to monitor Nrf2 antioxidant response pathway activity.and screen for activators or inhibitors of the Nrf2 antioxidant response pathway. |
Human Myc Reporter Cell Line |
ABC-RC0108 |
AcceGen |
1 vial |
Ask for price |
Description: Human Myc Reporter Cell Line is used to monitor Myc pathway activity and screen for activators or inhibitors of the Myc pathway. |
Human GAL4 Reporter Cell Line |
ABC-RC0086 |
AcceGen |
1 vial |
Ask for price |
Description: Human GAL4 Reporter Cell Line is an ideal product for monitoring biological activity |
Human ISRE Reporter Cell Line |
ABC-RC0101 |
AcceGen |
1 vial |
Ask for price |
Description: Human ISRE Reporter Cell Line can be used for the following applications: • Monitor IFNa-induced activity and the JAK/STAT pathway activity.• Screen for activators or inhibitors of the JAK/STAT signaling pathway. |
Human NFAT Reporter Cell Line |
ABC-RC0113 |
AcceGen |
1 vial |
Ask for price |
Description: Human NFAT Reporter Cell Line can be used as follows: • Monitor intracellular calcium levels. • Screen for activators or inhibitors of PKC/ Ca2+ pathway. • Screen for agonists or antagonists of T cell receptors. • Control for immune checkpoint NFAT reporter cell lines. |
Human RARα Reporter Cell Line |
ABC-RC0119 |
AcceGen |
1 vial |
Ask for price |
Description: The RARa Reporter (Luc)-HEK293 Cell Line is designed for monitoring the activity of retinoic acid receptor alpha (RARa). Application: • Monitor RARa-regulated pathway activity• Screen agonists or antagonists of RAR?. |
CSL Reporter - HEK293 Cell line |
79754 |
BPS Bioscience |
2 vials |
EUR 2275 |
Description: The Notch CSL Reporter - HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) stably integrated into HEK293 cells. Transfection of this cell line with a Notch expression vector and activation of the Notch pathway leads to expression of luciferase reporter. This cell line is validated with a Notch1DelE expression vector, which is constitutively processed by γ-secretase, leading to the release of NICD and the expression of luciferase. |
GAL4 Reporter Kit (Glucocorticoid Receptor Pathway) |
60522 |
BPS Bioscience |
500 rxns. |
EUR 565 |
Description: The Glucocorticoid Receptor Pathway Reporter Kit is designed for monitoring the activity of the glucocorticoid signaling pathway in cultured cells. The kit contains a transfection-ready expression vector for the glucocorticoid receptor ligand binding domain that is fused to the DNA binding domain (DBD) of GAL4 (GAL4 DBD-GR). This fusion construct activates firefly luciferase expression under the control of a multimerized GAL4 upstream activation sequence (UAS). This allows for specific detection of glucocorticoid-induced activation of the glucocorticoid receptor without the need for individual transcriptional targets and with low crossreactivity for other nuclear receptor pathways. The GAL4/UAS reporter is premixed with constitutively expressing Renilla (sea pansy) luciferase vector, which serves as an internal positive control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical for determining pathway-specific effects and background luciferase activity. |
NF-κB Reporter Kit (NF-κB Signaling Pathway) |
60614 |
BPS Bioscience |
500 rxns. |
EUR 650 |
Description: The NF-κB Reporter kit is designed for monitoring the activity of the NF-κB signaling pathway in the cultured cells. The kit contains transfection-ready NF-κB luciferase reporter vector. This reporter contains a firefly luciferase gene under the control of multimerized NF-κB responsive element located upstream of a minimal promoter. The NF-κB reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector, which serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively-expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains a firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical to determining pathway specific effects and background luciferase activity. |
STAT3 Reporter Jurkat Cell Line |
78497 |
BPS Bioscience |
2 vials |
EUR 1900 |
Description: The STAT3 Reporter Jurkat cell line is designed for monitoring the STAT3 signal transduction pathway. It contains a firefly luciferase gene driven by STAT3 response elements located upstream of the minimal TATA promoter. After activation by cytokines or growth factors, endogenous STAT3 binds to the DNA response elements, inducing transcription of the luciferase reporter gene. |
GFP Reporter Cell Line-HEK293 |
ABC-RC0001 |
AcceGen |
1 vial |
Ask for price |
Description: GFP Reporter Cell Line-293 stably expresses GFP and blasticidin-resistant genes.Both GFP and blasticidin-resistant genes are introduced into parental 293 cells using lentivirus. |
SRE Luciferase Reporter Lentivirus |
78627 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The SRE (Serum Response Element) Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by the Serum Response Element located upstream of the minimal TATA promoter . After transduction, activation of the MAPK/ERK signaling pathway in the target cells can be monitored by measuring the luciferase activity. |
Myc Luciferase Reporter Lentivirus |
78628 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The Myc Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by the Myc response element located upstream of the minimal TATA promoter and an antibiotic selection gene (puromycin) for the selection of stable clones. After transduction, the Myc signaling pathway in the target cells can be monitored by measuring the luciferase activity. |
UAS Luciferase Reporter Lentivirus |
78631 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The UAS (Upstream Activation Sequence) Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by a multimerized GAL4 upstream activation sequence (UAS) located upstream of the minimal TATA promoter and an antibiotic selection gene (puromycin) for the selection of stable clones. After transduction, the UAS-controlled signaling pathway in the target cells can be monitored by measuring the luciferase activity. |
p53 Luciferase Reporter Lentivirus |
78666 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The p53 Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce most types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by p53 response elements located upstream of the minimal TATA promoter (Figure 1) and an antibiotic selection gene (puromycin) for the selection of stable clones. After transduction, p53-regulated gene expression in the target cells can be monitored by measuring the luciferase activity. |
HRE Luciferase Reporter Lentivirus |
78668 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The Hypoxia Response Element (HRE) Luciferase Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce most types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by four copies of a hypoxia response elements (HRE) located upstream of the minimal TATA promoter (Figure 1) and an antibiotic selection gene (puromycin) for the selection of stable clones. After transduction, the induction of hypoxia in the target cells can be monitored by measuring the luciferase activity. |
ARE Luciferase Reporter Lentivirus |
79869 |
BPS Bioscience |
500 µl x 2 |
EUR 875 |
Description: The Nrf2 antioxidant response pathway plays an important role in the cellular antioxidant defense. Nrf2, a basic leucine zipper transcription factor, induces the expression of antioxidant and phase II enzymes by binding to the ARE (antioxidant response element) region of the gene promoter. Under basal conditions, Nrf2 is retained in the cytosol by binding to the cytoskeletal protein Keap1. Upon exposure to oxidative stress or other ARE activators, Nrf2 is released from Keap1 and translocates to the nucleus, where it can bind to the ARE, leading to the expression of antioxidant and phase II enzymes that protect the cell from oxidative damage. The ARE Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by ARE located upstream of the minimal TATA promoter. After transduction, activation of the Nrf2 antioxidant response pathway in the target cells can be monitored by measuring the luciferase activity. |
NF-κB eGFP Reporter Lentivirus |
79926 |
BPS Bioscience |
500 µl x 2 |
EUR 820 |
Description: The NF-κB eGFP Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an enhanced GFP gene driven by the NF-κB response element located upstream of the minimal TATA promoter. After transduction, activation of the NF-κB signaling pathway in the target cells can be monitored by examining eGFP expression. |
TEAD Luciferase Reporter Lentivirus |
79833 |
BPS Bioscience |
500 µl x 2 |
EUR 875 |
Description: The Hippo pathway regulates cell proliferation and cell death. It is activated by high cell density and cell stress to stop cell proliferation and induce apoptosis. The mammalian Hippo pathway comprises MST kinases and LATS kinases. When the Hippo pathway is activated, MST kinases phosphorylate LATS kinases, which phosphorylate transcriptional co-activators YAP and TAZ. Unphosphorylated YAP and TAZ remain in nucleus and interact with TEAD/TEF transcriptional factors to turn on cell cycle-promoting gene transcription. However, when phosphorylated, YAP and TAZ are recruited from the nucleus to the cytosol, so that the YAP and TAZ-dependent gene transcription is turned off. Dysfunction of the Hippo pathway is frequently detected in human cancer and its down-regulation correlates with the aggressive properties of cancer cells and poor prognosis. The TEAD Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by the TEAD response elements located upstream of the minimal TATA promoter. After transduction, activation of the Hippo pathway in the target cells can be monitored by measuring the luciferase activity._x000D_ |
CRE/CREB Reporter Kit (cAMP/PKA Signaling Pathway) |
60611 |
BPS Bioscience |
500 rxns. |
EUR 590 |
Description: The CRE/CREB Reporter kit is designed for monitoring the activity of the cAMP/PKA signaling pathway in cultured cells. The kit contains transfection-ready CRE luciferase reporter. This reporter contains the firefly luciferase gene under the control of multimerized cAMP response element (CRE) located upstream of a minimal promoter. Elevation of the intracellular cAMP level activates cAMP response element binding protein (CREB) to bind CRE and induces the expression of luciferase. The CRE reporter is premixed with constitutively-expressing Renilla (sea pansy) luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with the constitutivelyexpressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, but without any additional response elements. The negative control is critical to determining pathway-specific effects and background luciferase activity. |
CRE/CREB eGFP Reporter Lentivirus |
78153 |
BPS Bioscience |
500 µl x 2 |
EUR 795 |
Description: The CRE/CREB eGFP Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an eGFP gene driven by a multimerized cAMP response element (CRE) located upstream of the minimal TATA promoter . After transduction, activation of the cAMP/PKA signaling pathway in the target cells can be monitored by examining eGFP expression. |
STAT3 Luciferase Reporter Lentivirus |
79744 |
BPS Bioscience |
500 µl x 2 |
EUR 860 |
Description: The STAT3 Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene under the control of STAT3-responsive element located upstream of the minimal TATA promoter. After transduction, activation of the STAT3 signaling pathway in the target cells can be monitored by measuring the luciferase activity._x000D_ |
STAT5 Luciferase Reporter Lentivirus |
79745 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The STAT5 Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene under the control of STAT5-responsive element located upstream of the minimal TATA promoter. After transduction, activation of the STAT5 signaling pathway in the target cells can be monitored by measuring the luciferase activity. |
CSF1R / SRE Reporter Kit (MAPK/ERK Signaling Pathway) |
79379 |
BPS Bioscience |
500 rxns. |
EUR 615 |
Description: The CSF1R SRE Reporter Kit is designed for monitoring the activity of the CSF1R signaling pathway in cultured cells. The kit contains a transfection-ready vector for CSF1R and SRE luciferase reporter vector. Upon ligand binding, active CSF1R will initiate the MAPK/ERK signaling pathway, leading to expression of the SRE-controlled reporter. This reporter contains the firefly luciferase gene under the control of multimerized SRE responsive elements located upstream of a minimal promoter. The SRE reporter is premixed with a constitutively-expressing Renilla luciferase vector that serves as an internal control for transfection efficiency._x000D_The kit also includes a non-inducible firefly luciferase vector premixed with constitutively- expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical for determining pathway-specific effects and the background luciferase activity. |
Notch Homolog 2 (NOTCH2) Magnetic Luminex Assay Kit |
LKU606844-96T |
Biomatik Corporation |
96T |
EUR 1062.6 |
Notch Homolog 3 (NOTCH3) Magnetic Luminex Assay Kit |
LKU606845-96T |
Biomatik Corporation |
96T |
EUR 1062.6 |
Notch Homolog 4 (NOTCH4) Magnetic Luminex Assay Kit |
LKU606846-96T |
Biomatik Corporation |
96T |
EUR 1062.6 |
GFP Reporter Cell Line-CHO/Blas |
ABC-RC0001L |
AcceGen |
1vial |
Ask for price |
Description: This CHO GFP Stable Cell Line is transformed from the CHO cells, andnbsp;stably expressing the humanizedandnbsp;GFPandnbsp;fluorescent protein. It was established by transduction of the enhanced GFP expression lentivirus containing aandnbsp;Blasticidinandnbsp;resistance marker. GFP is constitutively expressed at a high-level under the enhanced CMV promoter (suCMV).andnbsp |
GFP Reporter Cell Line-CHO/Puro |
ABC-RC002L |
AcceGen |
1 vial |
Ask for price |
Description: This CHO GFP Stable Cell Line is transformed from the CHO cells, andnbsp;stably expressing the humanizedandnbsp;GFPandnbsp;fluorescent protein. It was established by transduction of the enhanced GFP expression lentivirus containing aandnbsp;Puromycin resistance marker. GFP is constitutively expressed at a high-level under the enhanced CMV promoter (suCMV).andnbsp |
Human HRE Reporter Cell Line–HeLa |
ABC-RC0095 |
AcceGen |
1 vial |
Ask for price |
Description: Human HRE Reporter Cell Line is derived from HeLa cell. Gentaur can provide high quality reporter cell line for monitoring biological activity |
Human ATF6 Reporter Cell Line–HeLa |
ABC-RC0080 |
AcceGen |
1 vial |
Ask for price |
Description: Human ATF6 Reporter Cell Line is derived from HeLa cells. It can be used for monitoring biological activity |
Human GR-GAL4 Reporter Cell Line |
ABC-RC0091 |
AcceGen |
1 vial |
Ask for price |
Description: Human GR-GAL4 Reporter Cell Line is an ideal product to monitor glucocorticoid signaling pathway activity and screen activators or inhibitors of the glucocorticoid signaling pathway. |
NFAT Reporter (Luc) - Jurkat Cell Line |
60621 |
BPS Bioscience |
2 vials |
EUR 2295 |
Description: The NFAT Reporter - Jurkat Cell Line contains a firefly luciferase gene under the control of the_x000D_NFAT response element stably integrated into Jurkat cells. This cell line has been validated for_x000D_response to thapsigargin, ionomycin, and phorbol 12-myristate 13-acetate (PMA). It is useful as_x000D_a control cell line for other NFAT reporter cell lines expressing various immune checkpoint_x000D_receptors. |
GAL4 Reporter (Luc)-HEK293 Cell Line |
60656 |
BPS Bioscience |
2 vials |
EUR 1095 |
Description: The GAL4 Reporter (Luc) - HEK293 Cell Line contains a firefly luciferase gene under the control of a multimerized GAL4 upstream activation sequence (UAS) stably integrated into HEK293 cells. The cell line does not contain any exogenous activators of the GAL4 reporter and can be used alongside BPS Cat. #60655 as a control. |
Rev-CEM-GFP HIV Reporter Cells |
HRC-4 |
101Bio |
1 vial of 5x10⁶ cells |
EUR 1500 |
Rev-CEM-Luc HIV Reporter Cells |
HRC-6 |
101Bio |
1 vial of 5x10⁶ cells |
EUR 1500 |
TLR8-NF-κB Stable Reporter 293 Cell Line |
T6412 |
ABM |
1x10^6 cells / 1.0 ml |
EUR 3950 |
Human SRE Reporter Cell Line - HEK293 |
ABC-RC0122 |
AcceGen |
1 vial |
Ask for price |
Description: Human SRE Reporter Cell Line is derived from HEK293. Application: • Monitor MAPK/ERK signaling pathway activity and SRF-mediated activity.• Screen for activators or inhibitors of the MAPK/ERK signaling pathway. |
PDE7A/CRE Reporter - HEK293 Cell Line |
60413 |
BPS Bioscience |
2 vials |
EUR 9270 |
Description: The PDE7A/CRE Reporter-HEK293 line contains the firefly luciferase gene under the control of CRE as well as a constitutive expression construct for human PDE7A (phosphodiesterase 7A, accession number NM_002603), both stably integrated into HEK293 cells. The luciferase expression level from the CRE reporter is used to monitor the activity of PDE7A in the cells. |
JAK pathway ISRE reporter cell line |
GWB-PSC83D |
GenWay Biotech |
1.5x10(6)cells |
Ask for price |
STAT5 Reporter (Luc) - Ba/F3 Cell line |
79772 |
BPS Bioscience |
2 vials |
EUR 2275 |
Description: The STAT5 Reporter (Luc)-Ba/F3 cell line is designed for monitoring STAT5 signal transduction pathways. It contains a firefly luciferase gene driven by the STAT5 response element located upstream of the minimal TATA promoter. After activation by cytokines or growth factors, endogenous STAT5 binds to the DNA response elements, inducing transcription of the luciferase reporter gene. |
IRF Reporter (Luc) - THP-1 Cell line |
79858 |
BPS Bioscience |
2 vials |
EUR 1810 |
Description: The Interferon Regulatory Factor (IRF) reporter (Luc)-THP-1 cell line is designed to study the activation and signaling of Cytosolic DNA Sensors (CDS) in human monocytic cell line THP-1. It contains a firefly luciferase gene driven by multimerized ISRE (Interferon Stimulated Response Element) located upstream of the minimal TATA promoter. _x000D_The cGAS-STING pathway acts to detect cytosolic DNA and induce an immune response. Briefly, upon binding DNA, the protein cGAS (cyclic GMP-AMP Synthase) triggers reaction of GTP and ATP to form cGAMP. cGAMP binds to STING (Stimulator of Interferon Genes) which triggers phosphorylation of IRF3 via TBK1. IRF3 can then bind to interferon-stimulated responsive elements (ISRE) in the nucleus and leads to IFN-α/β production. The IRF reporter (Luc)-THP-1 cell line is highly responsive to STING and CDS ligands. |
NF-κB Luciferase Reporter Lentivirus |
79564 |
BPS Bioscience |
500 µl x 2 |
EUR 875 |
Description: The NF-κB Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by four copies of the NF-κB response element located upstream of the minimal TATA promoter. After transduction, activation of the NF-κB signaling pathway in the target cells can be monitored by measuring the luciferase activity. |
STAT3 Reporter (eGFP)-HEK293 Cell Line |
78319 |
BPS Bioscience |
2 vials |
EUR 3390 |
Description: The STAT3 Reporter (eGFP)-HEK293 cell line is designed to monitor the STAT3 signal transduction pathway. It contains an eGFP gene driven by STAT3 response elements located upstream of the minimal TATA promoter. After activation by cytokines and growth factors, endogenous STAT3 binds to the DNA response elements, inducing transcription of the eGFP reporter gene. |
Human NFAT Reporter Cell Line– HEK293 |
ABC-RC0111 |
AcceGen |
1 vial |
Ask for price |
Description: Human NFAT Reporter Cell Line is derived from HEK293. This reporter cell line is an ideal product to monitor the blogical ativity |
Human NFAT Reporter Cell Line–RAW264.7 |
ABC-RC0112 |
AcceGen |
1 vial |
Ask for price |
Description: Human NFAT Reporter Cell Line is derived from RAW264.7. This reporter cell line is an ideal product to monitor the blogical ativity |
TIGIT / NFAT Reporter - Jurkat Cell Line |
60538 |
BPS Bioscience |
2 vials |
EUR 10855 |
Description: Recombinant Jurkat cell line constitutively expressing a full length human TIGIT (T_x000D_cell Immunoreceptor with Immunoglobulin and ITIM domain; VSTM3), and a firefly luciferase_x000D_gene under the control of nuclear factor of activator T cells (NFAT) response element. Both_x000D_TIGIT and NFAT constructs have been stably integrated into Jurkat cells. TIGIT expression has_x000D_been confirmed by Western Blot, and TIGIT-specific NFAT response has been validated using a_x000D_TIGIT ligand, CD155 (PVR). |
CRE/CREB Luciferase Reporter Lentivirus |
79580 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The main role of the cAMP response element, or CRE, is mediating the effects of Protein Kinase A (PKA) by way of transcription. Upon phosphorylation, CREB forms a functionally active dimer that binds the CRE element within the promoters of target genes and activates transcription. CRE is at the focus of many extracellular and intracellular signaling pathways, including cAMP, calcium, GPCR (G-protein coupled receptors) and neurotrophins. The cAMP/PKA signaling pathway is critical to numerous life processes in living organisms.The CRE/CREB Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by multimerized cAMP response element (CRE) located upstream of the minimal TATA promoter. After transduction, activation of the cAMP/PKA signaling pathway in the target cells can be monitored by measuring the luciferase activity. |
Oct4 CR4-pGreenFire Response Reporter |
SR20070-PA-1 |
SBI |
10 ug |
EUR 1662 |
Bald VSV Delta G (Luciferase Reporter) |
78636-1 |
BPS Bioscience |
100 µl |
EUR 395 |
Description: The bald VSV Delta G (Luciferase Reporter) was produced without envelope glycoproteins. It contains the firefly luciferase gene as the reporter. The bald VSV Delta G (Luciferase Reporter) can serve as a negative control when studying virus entry initiated by specific interactions between virus particles and receptors. |
Bald VSV Delta G (Luciferase Reporter) |
78636-2 |
BPS Bioscience |
500 µl x 2 |
EUR 1995 |
Description: The bald VSV Delta G (Luciferase Reporter) was produced without envelope glycoproteins. It contains the firefly luciferase gene as the reporter. The bald VSV Delta G (Luciferase Reporter) can serve as a negative control when studying virus entry initiated by specific interactions between virus particles and receptors. |
Human GATA3 Reporter Cell Line – HEK293 |
ABC-RC0087 |
AcceGen |
1 vial |
Ask for price |
Description: Human GATA3 Reporter Cell Line is dervided from HEK293 cell. Gentaur can provide high quality reporter cell line for monitoring biological activity |
Human Gli Reporter Cell Line-NIH3T3 |
ABC-RC0090 |
AcceGen |
1 vial |
Ask for price |
Description: Human Gli Reporter Cell Line is derived from NIH3T3. This reporter cell line can be used as the following application: • Monitor Hedgehog signaling pathway activity. • Screen for activators or inhibitors of the Hedgehog signaling pathway. |
Human MDA5 Reporter Cell Line – HEK293T |
ABC-RC0103 |
AcceGen |
1 vial |
Ask for price |
Description: Human MDA5 Reporter Cell Line is derived from HEK293T. This reporter cell line is an ideal product to monitor the blogical ativity |
Human STAT3 Reporter Cell Line–HEK293 |
ABC-RC0125 |
AcceGen |
1 vial |
Ask for price |
Description: Human Stat3 Reporter Cell Line is derived from HEK293. This reporter cell line is an ideal product to monitor the blogical ativity |
NF- κB Reporter (Luc) - Raw 264.7 Cell line |
79978 |
BPS Bioscience |
2 vials |
EUR 2045 |
Description: The NF-κB reporter (Luc)-Raw 264.7 cell line is designed for monitoring nuclear factor Kappa B (NF-κB) signal transduction pathways. It contains a firefly luciferase gene driven by four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or stimulants of lymphokine receptors, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene. |
Human PD-L1 Reporter Cell Line- CHO |
ABC-RC0118 |
AcceGen |
1 vial |
Ask for price |
Description: Human PD-L1 Reporter Cell Line is derived from CHO. It can be used to screen PD-L1 antibodies for binding affinity and biological assays. |
Thyretain TBI Blocking Reporter BioAssay |
40-35010 |
Quidel |
kit |
EUR 1456.58 |
Sox2 SRR2-pGreenFire Response Reporter |
SR20071-PA-1 |
SBI |
10 ug |
EUR 1662 |
Human TLR8 Reporter Cell Line-HEK293 |
ABC-RC0058 |
AcceGen |
1 vial |
Ask for price |
Description: Human TLR8 Reporter Cell Line can be used for TLR8 flow cytometric calibration and detection control as well as TLR8-dependent functional assays. TLR8 expression in this cell line has been validated by Western blotting and flow cytometry. |
Human TLR9 Reporter Cell Line-HEK293 |
ABC-RC0060 |
AcceGen |
1 vial |
Ask for price |
Description: Human TLR9 Reporter Cell Line is a stably transfected HEK 293 line which expresses full-length human Toll-like receptor 9 (TLR9) with no epitope tag. |
Human CD47 Reporter Cell Line-HEK293 |
ABC-RC0085 |
AcceGen |
1 vial |
Ask for price |
Description: Human CD47 Reporter Cell Line is Ideal for protein binding analyses and studying SIRPa receptor activity. |
Human hTDO Reporter Cell Line-HEK293 |
ABC-RC0096 |
AcceGen |
1 vial |
Ask for price |
Description: Human hTDO Reporter Cell Line is derived from Hek293. It can be usef to monitor TDO pathway activity and screen for activators or inhibitors of TDO in a cellular context |
NF- κB Reporter (Luc) - THP-1 Cell Line |
79645 |
BPS Bioscience |
2 vials |
EUR 1900 |
Description: The NF-κB reporter (Luc)-THP-1 cell line is designed for monitoring nuclear factor Kappa B (NF-κB) signal transduction pathways. It contains a firefly luciferase gene driven by four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or stimulants of lymphokine receptors, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene. |
Human CD40/NF-kB Reporter Cell Line |
ABC-RC0084 |
AcceGen |
1 vial |
Ask for price |
Description: The CD40 NF-kB Reporter HEK293 Stable Cell Line is ideal for High Throughput Screening (HTS) to identify potential CD40 agonistic monoclonal antibodies and CD40-specific inhibitors. |
PD-1 / NFAT Reporter - Jurkat Cell Line |
60535 |
BPS Bioscience |
2 vials |
EUR 11375 |
Description: Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of human PD-1 (Programmed Cell Death 1, PDCD1, SLEB2, CD279, GenBank Accession #NM_005018)._x000D_ |
NF-κB Reporter (Luc) - HCT116 Cell Line |
60623 |
BPS Bioscience |
2 vials |
EUR 1095 |
Description: NF-B luciferase reporter construct is stably integrated into the genome of HCT-116 cells. The firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene._x000D_The NF-κB-luciferase/HCT-116 cell line is suitable for monitoring the activity of NF-κB signaling in response to stimulants such as the cytokines TNF and IL-1β, pathogen-associated molecular pattern (PAMP) (i.e. flagellin) or endogenous damage-associated molecular pattern (DAMP) molecules (i.e. NOD1 ligand) (see application references). It is also suitable for establishing cell-based screens for inhibitors that target specific NF-κB stimulating molecules. This cell line can be further modified to allow investigation of downstream NF-κB activities as a result of targeted genetic mutation(s). |
NF-κB reporter (Luc) - HEK293 Cell line |
60650 |
BPS Bioscience |
2 vials |
EUR 1365 |
Description: The NF-κB reporter (Luc) HEK293 cell line is designed to monitor nuclear factor Kappa B (NF-κB) activity. It contains a firefly luciferase gene driven by four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or agonists of lymphokine receptors, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene. The cell line has been functionally validated in response to human TNF-α, IL-1β, and IL-17. |
Rev-A3-GFP/Luc HIV Reporter Cells |
HRC-3 |
101Bio |
1 vial of 5x10⁶ cells |
EUR 1800 |
NF-kB reporter (Luc) - HEK293 Cell line |
GWB-PS76F8 |
GenWay Biotech |
2X10(6)cells |
Ask for price |
NFAT Luciferase-RFP Reporter Lentivirus |
78617-H |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The NFAT Luciferase-RFP Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase and RFP (Red Fluorescent Protein) cassette driven by the NFAT response element located upstream of the minimal TATA promoter and a hygromycin or puromycin selection gene to generate stable clones. After transduction, activation of the NFAT signaling pathway in the target cells can be monitored by measuring the luciferase activity or RFP expression. RFP fluoresces red-orange when excited; it has an excitation wavelength of 553 nm, and an emission wavelength of 574 nm. |
NFAT Luciferase-RFP Reporter Lentivirus |
78617-P |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The NFAT Luciferase-RFP Reporter Lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to transduce almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase and RFP (Red Fluorescent Protein) cassette driven by the NFAT response element located upstream of the minimal TATA promoter and a hygromycin or puromycin selection gene to generate stable clones. After transduction, activation of the NFAT signaling pathway in the target cells can be monitored by measuring the luciferase activity or RFP expression. RFP fluoresces red-orange when excited; it has an excitation wavelength of 553 nm, and an emission wavelength of 574 nm. |
Negative Control eGFP Reporter Lentivirus |
79927 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The Negative Control eGFP Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The particles contain an enhanced Green Fluorescent Protein (eGFP) gene under the control of a minimal TATA promoter, without any additional transcriptional response elements. |
Human Hido1 Reporter Cell line--HEK293 |
ABC-RC0093 |
AcceGen |
1 vial |
Ask for price |
Description: Human Hido1 Reporter Cell line is derived from HEK293. This reporter cell line is used for monitoring IDO1 pathway activity and screening for activators or inhibitors of IDO1 in a cellular context |
PAI-1 Reporter (Luc) - Mv1 Lu Cell Line |
60544 |
BPS Bioscience |
2 vials |
EUR 3595 |
Description: PAI-1 Reporter (Luc)-Mv1 Lu cell line is designed for monitoring transforming growth factor β (TGF-β)-induced plasminogen activator inhibitor-1 (PAI-1) expression. Transforming growth factor-β (TGF-β) is a potent regulator of cellular differentiation, proliferation, migration, and protein expression._x000D__x000D_PAI-1 Reporter (Luc) -Mv1 Lu cell line contains a firefly luciferase gene under the control of PAI-1 responsive elements stably integrated into Mv1 Lu (NBL-7) cells, showing TGF-β pathway response. This cell line is validated for the TGF-β response to the induction of PAI-1 gene expression through luciferase activity. _x000D_ |
NF-κB Reporter CHO Cell Line (EL-1) |
T6434 |
ABM |
1x10^6 cells / 1.0 ml |
EUR 3950 |
Rev-CEM-GFP/Luc HIV Reporter Cells |
HRC-5 |
101Bio |
1 vial of 5x10⁶ cells |
EUR 1500 |
Bald Lentiviral Pseudovirion (eGFP Reporter) |
79987 |
BPS Bioscience |
500 µl x 2 |
EUR 835 |
Description: The bald lentiviral pseudovirion was produced without envelope glycoproteins such as VSV-G or SARS-CoV-2 spike. It contains the eGFP gene driven by a CMV promoter as the reporter. The bald lentiviral pseudovirion can serve as a negative control when studying virus entry initiated by specific interactions between virus particles and receptors._x000D_ |
NF-κB reporter (Luc) - NIH/3T3 Cell line |
79469 |
BPS Bioscience |
2 vials |
EUR 1900 |
Description: The NF-κB reporter (Luc)-NIH/3T3 cell line is designed for monitoring nuclear factor Kappa B (NF-κB) signal transduction pathways. It contains a firefly luciferase gene driven by four copies of the NF-κB response element located upstream of the minimal TATA promoter. After activation by pro-inflammatory cytokines or stimulants of lymphokine receptors, endogenous NF-κB transcription factors bind to the DNA response elements, inducing transcription of the luciferase reporter gene. |
Human MIP-2 Reporter Cell Line – HEK293 |
ABC-RC0104 |
AcceGen |
1 vial |
Ask for price |
Description: Human MIP-2 Reporter Cell Line is derived from HEK293. This reporter cell line is an ideal product to monitor the blogical ativity |
Human MIP-2 Reporter Cell Line–RAW264.7 |
ABC-RC0105 |
AcceGen |
1 vial |
Ask for price |
Description: Human MIP-2 Reporter Cell Line is derived from RAW264.7. This reporter cell line is an ideal product to monitor the blogical ativity |
Human 5-HT1A (Luc) HEK293 Reporter Cell |
CHEK-ATF131 |
ACROBIOSYSTEMS |
2Vials |
EUR 14209.6 |
|
Description: This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. |
Rev-A3R5-GFP/Luc HIV Reporter Cells |
HRC-2 |
101Bio |
1 vial of 5x10⁶ cells |
EUR 1900 |
Cre Recombinase Reporter HEK293 Cell Line |
CRE01 |
ALSTEM |
1 Vial |
EUR 2268 |
NF-κB Reporter (Luc) - CHO-K1 Cell Line |
60622 |
BPS Bioscience |
2 vials |
EUR 1095 |
Description: An NF-κB luciferase reporter construct is stably integrated into the genome of CHO-K1 cells. The firefly luciferase gene is controlled by the NF-κB response element located upstream of the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene._x000D_The NF-κB-luciferase / CHO-K1 cell line is suitable for monitoring the activity of NF-κB transcription factor through luminescence readout.). This cell line responds to human cytokine IL-1β, responds moderately to human TNF, and does not respond to human IFN-λ (2 µg/ml). Reducing the amount of serum during incubation period may increase the sensitivity to cytokines. Since CHO-K1 cells do not express endogenous human proteins, this cell line provides an excellent platform to enable exogenous expression of a protein of interest to study its downstream effect on NF-κB signaling. |
Notch Signaling Pathway Notch1/CSL Report Cell Line-HEK293 |
ABC-RC123D |
AcceGen |
1 vial |
Ask for price |
Description: The Notch CSL Reporter andndash; HEK293 cell line contains the firefly luciferase gene under the control of Notch-response elements (CSL responsive elements) alone with expression construct for Notch1 E (NOTCH1 that has a deletion of the entire extracellular domain) stably integrated into HEK293 cells. Inside the cells, the Notch1 E can be cleaved by andgamma;-secretase. The active Notch1 NICD is released to nucleus and induces the constitutive expression of luciferase reporter. The cell line is validated for the inhibition of the expression of luciferase reporter using a known inhibitor of the Notch signaling pathway. |
Human AP-1 Reporter Cell Line-HEK293 |
ABC-RC0078 |
AcceGen |
1 vial |
Ask for price |
Description: Human AP-1 Reporter Cell Line is used for there applications: • Monitor the JNK signaling pathway activity and AP1-mediated activity.• Screen for activators or inhibitors of the JNK signaling pathway. |
Human CD27 Reporter Cell Line-CHO-K1 |
ABC-RC0083 |
AcceGen |
1 vial |
Ask for price |
Description: Human CD27 Reporter Cell Line is derived from CHO-K. It can be used for monitoring biological activity |
RARα Reporter - HEK293 Recombinant Cell Line |
60503 |
BPS Bioscience |
2 vials |
EUR 2240 |
Description: The RARα Reporter (Luc)-HEK293 Cell Line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARα (NM_000964). |
RARβ Reporter - HEK293 Recombinant Cell Line |
60603 |
BPS Bioscience |
2 vials |
EUR 1895 |
Description: The RARβ Reporter (Luc)-HEK293 cell line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARβ (accession # P10826-2). |
RARγ Reporter - HEK293 Recombinant Cell Line |
60604 |
BPS Bioscience |
2 vials |
EUR 1895 |
Description: The RARγ Reporter (Luc)-HEK293 cell line contains a firefly luciferase gene under the control of retinoic acid response elements stably integrated into HEK293 cells along with full length human RARγ (accession #P13631-1). |
Paleo-distribution modelling revealed the vary dynamics of M. himalaica to be extremely delicate to geo-climatic change with restricted long-distance dispersal capability and potential evolutionary adaptation. Furthermore, river drainage programs, valleys and mountain gorges had been recognized as the corridors for inhabitants genetic connectivity amongst the populations. It is concluded that current intense mountain uplift and subsequent climatic alterations together with monsoonal modifications since Pliocene or early Pleistocene formulated fragmented habitats and numerous ecology that ruled the habitat connectivity, evolutionary and demographic historical past of M. himalaica. The integrative genetic and geospatial methodology would deliver new implications for the evolutionary course of and conservation precedence of HHM endemic species.